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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAG3xjybJe0VNuoWzv7qtpA-VX6RRudfg7adhKTGqVgM0#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAG3xjybJe0VNuoWzv7qtpA-VX6RRudfg7adhKTGqVgM0#_4 http://www.w3.org/ns/prov#value Treatment of cells with a specific E-cadherin neutralizing antibodies SHE 78-7 (5 microg/ml) or HECD-1 resulted in a dose-dependent decrease in the phosphorylation levels of MEK and Raf which was induced by E-cadherin-mediated cell adhesion in the presence of calcium. It was also proved that the activation of MEK and MAPK takes place in a EGFR-dependent manner. These results indicate that cell adhesion through E-cadherin results in the activation of Raf/MEK/MAPK pathway. http://www.tkuhn.ch/bel2nanopub/RAG3xjybJe0VNuoWzv7qtpA-VX6RRudfg7adhKTGqVgM0#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15938214 http://www.tkuhn.ch/bel2nanopub/RAG3xjybJe0VNuoWzv7qtpA-VX6RRudfg7adhKTGqVgM0#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAG3xjybJe0VNuoWzv7qtpA-VX6RRudfg7adhKTGqVgM0#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15938214 http://www.tkuhn.ch/bel2nanopub/RAG3xjybJe0VNuoWzv7qtpA-VX6RRudfg7adhKTGqVgM0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAG3xjybJe0VNuoWzv7qtpA-VX6RRudfg7adhKTGqVgM0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAG3xjybJe0VNuoWzv7qtpA-VX6RRudfg7adhKTGqVgM0#_4 http://www.tkuhn.ch/bel2nanopub/RAG3xjybJe0VNuoWzv7qtpA-VX6RRudfg7adhKTGqVgM0#pubinfo http://www.tkuhn.ch/bel2nanopub/RAG3xjybJe0VNuoWzv7qtpA-VX6RRudfg7adhKTGqVgM0 http://purl.org/dc/terms/created 2014-07-03T14:30:35.844+02:00 http://www.tkuhn.ch/bel2nanopub/RAG3xjybJe0VNuoWzv7qtpA-VX6RRudfg7adhKTGqVgM0 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAG3xjybJe0VNuoWzv7qtpA-VX6RRudfg7adhKTGqVgM0 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234