. . . . . . . . . . . . . . . . "tscript(p(HGNC:CTCF)) => r(HGNC:\"HLA-DQA1\")" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "CTCF is required for interactions between XL9 and HLA-DRB1 and HLA-DQA1 and for maximal histone modification of the promoter regions. CTCF was found to interact with XL9 by in vivo (chromatin immunoprecipitation [ChIP]) and in vitro (electrophoretic mobility shift assay) assays (14) (15). To test the hypothesis that CTCF plays a role in the regulation of the flanking MHC genes HLA-DRB1 and HLA-DQA1, siRNAs were used to knockdown the expression of CTCF.Assessment of HLA-DRB1 and HLA-DQA1 mRNA expression during the knockdown time course assays showed a marked reduction in steady-state mRNA levels of both HLA-DRB1 and HLA-DQA1 when siRNAs to CTCF but not GFP were used (Fig. 1 C). " . . "Selventa" . . . . "2014-07-03T14:33:18.653+02:00"^^ . . .