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[Addition of the O2- scavenger 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl to cultures resulted in increased infection, suggesting that O2- enhances macrophage leishmanicidal activity.The importance of NO. produced by inducible NO synthase (iNOS) in controlling murine leishmaniasis is established, but its role in human macrophages has been debated.We detected NO. in supernatants from murine, but not human, macrophages infected with L. chagasi.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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