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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAFty0vjtbI58JLg44dweV7bLhC2q7YWAlmtikyMSBuMA#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAFty0vjtbI58JLg44dweV7bLhC2q7YWAlmtikyMSBuMA#_3 http://www.w3.org/ns/prov#value To determine a possible role of Egr-1 in the beta-cell, Egr-1 expression in INS-1 cells was silenced using RNA interference (RNAi). Glucose-stimulated insulin secretion in these cells was then measured using ELISA and cell proliferation was measured by [(3)H]thymidine incorporation. Small interfering RNA (siRNA)-mediated silencing of the Egr-1 gene inhibited its induction by glucose but had no observable effect on glucose-stimulated insulin secretion. However, Egr-1 gene silencing did inhibit proliferation of INS-1 cells in a glucose-independent manner. http://www.tkuhn.ch/bel2nanopub/RAFty0vjtbI58JLg44dweV7bLhC2q7YWAlmtikyMSBuMA#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16087718 http://www.tkuhn.ch/bel2nanopub/RAFty0vjtbI58JLg44dweV7bLhC2q7YWAlmtikyMSBuMA#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAFty0vjtbI58JLg44dweV7bLhC2q7YWAlmtikyMSBuMA#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16087718 http://www.tkuhn.ch/bel2nanopub/RAFty0vjtbI58JLg44dweV7bLhC2q7YWAlmtikyMSBuMA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAFty0vjtbI58JLg44dweV7bLhC2q7YWAlmtikyMSBuMA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAFty0vjtbI58JLg44dweV7bLhC2q7YWAlmtikyMSBuMA#_3 http://www.tkuhn.ch/bel2nanopub/RAFty0vjtbI58JLg44dweV7bLhC2q7YWAlmtikyMSBuMA#pubinfo http://www.tkuhn.ch/bel2nanopub/RAFty0vjtbI58JLg44dweV7bLhC2q7YWAlmtikyMSBuMA http://purl.org/dc/terms/created 2014-07-03T14:32:48.575+02:00 http://www.tkuhn.ch/bel2nanopub/RAFty0vjtbI58JLg44dweV7bLhC2q7YWAlmtikyMSBuMA http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAFty0vjtbI58JLg44dweV7bLhC2q7YWAlmtikyMSBuMA http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234