sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_6 ;
    pav:version "1.4" .
  sub:_5 prov:value "RET stimulation triggers many other signaling intermediates, including CREB [42], p38MAPK [42], NFkB [43], ERK5 (BMK1) [44], phosphoinositide-dependent kinase 1 (PDK1) 45, cyclin-dependent kinase 5 (CDK5) [46] and PKC isoforms [47 48] (fig. 3). Although the mechanism of activation of these pathways remains to be elucidated, Y1062 is important for most of them. In particular, Ras/ERK- and PI3K-triggering by Y1062 is essential for full activation of CREB and NFkB [42]. A novel RET interactor designated Grap-2 has been found to negatively regulate NFkB activation [43]." ;
    prov:wasQuotedFrom pubmed:15583857 .
  sub:_6 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:15583857 ;
    prov:wasDerivedFrom beldoc: , sub:_5 .
}