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[SIRT1, a nicotinamide adenine dinucleotide(+)-dependent histone/protein deacetylase, plays a crucial role in various physiological processes, such as aging, metabolism, neurogenesis and apoptosis, owing to its ability to deacetylate numerous substrates, such as histone and NF-?B, which is implicated as an exacerbation factor in ATL.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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