[ { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFVf4bRqu9QdH11xJE2_5lgsxLYVjY3d_-Q0efP-nRZM", "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ], "http://www.nanopub.org/nschema#hasAssertion" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFVf4bRqu9QdH11xJE2_5lgsxLYVjY3d_-Q0efP-nRZM#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFVf4bRqu9QdH11xJE2_5lgsxLYVjY3d_-Q0efP-nRZM#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFVf4bRqu9QdH11xJE2_5lgsxLYVjY3d_-Q0efP-nRZM#pubinfo" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFVf4bRqu9QdH11xJE2_5lgsxLYVjY3d_-Q0efP-nRZM#Head" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFVf4bRqu9QdH11xJE2_5lgsxLYVjY3d_-Q0efP-nRZM#_1", "@type" : [ "http://amigo.geneontology.org/amigo/term/GO:0016301" ], "http://semanticscience.org/resource/SIO_000139" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFVf4bRqu9QdH11xJE2_5lgsxLYVjY3d_-Q0efP-nRZM#_2" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFVf4bRqu9QdH11xJE2_5lgsxLYVjY3d_-Q0efP-nRZM#_2", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://www.informatics.jax.org/marker/MGI:97847" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFVf4bRqu9QdH11xJE2_5lgsxLYVjY3d_-Q0efP-nRZM#_3", "@type" : [ "http://amigo.geneontology.org/amigo/term/GO:0016301" ], "http://semanticscience.org/resource/SIO_000139" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFVf4bRqu9QdH11xJE2_5lgsxLYVjY3d_-Q0efP-nRZM#_4" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFVf4bRqu9QdH11xJE2_5lgsxLYVjY3d_-Q0efP-nRZM#_4", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://resource.belframework.org/belframework/1.0/namespace/selventa-named-mouse-protein-families/MEK1%2F2%20Family" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFVf4bRqu9QdH11xJE2_5lgsxLYVjY3d_-Q0efP-nRZM#_5", "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ], "http://purl.obolibrary.org/obo/BFO_0000066" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFVf4bRqu9QdH11xJE2_5lgsxLYVjY3d_-Q0efP-nRZM#_3" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ { "@id" : "http://www.selventa.com/vocabulary/increases" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFVf4bRqu9QdH11xJE2_5lgsxLYVjY3d_-Q0efP-nRZM#_1" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFVf4bRqu9QdH11xJE2_5lgsxLYVjY3d_-Q0efP-nRZM#assertion", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "kin(p(MGI:Raf1)) -> kin(p(PFM:\"MEK1/2 Family\"))" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFVf4bRqu9QdH11xJE2_5lgsxLYVjY3d_-Q0efP-nRZM#assertion" }, { "@graph" : [ { "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel", "http://purl.org/dc/elements/1.1/description" : [ { "@value" : "Approximately 61,000 statements." } ], "http://purl.org/dc/elements/1.1/rights" : [ { "@value" : "Copyright (c) 2011-2012, Selventa. All rights reserved." } ], "http://purl.org/dc/elements/1.1/title" : [ { "@value" : "BEL Framework Large Corpus Document" } ], "http://purl.org/pav/authoredBy" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFVf4bRqu9QdH11xJE2_5lgsxLYVjY3d_-Q0efP-nRZM#_7" } ], "http://purl.org/pav/version" : [ { "@value" : "1.4" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFVf4bRqu9QdH11xJE2_5lgsxLYVjY3d_-Q0efP-nRZM#_6", "http://www.w3.org/ns/prov#value" : [ { "@value" : "Although activation of RAF and AKT is clearly sufficient to repress p27Kip1 expression, these experiments do not address whether the PI3'-kinase-PDK1-AKT and the RAF-MEK- ERK pathways are required for the repression of p27Kip1 in response to mitogenic stimulation or oncogenic transformation. To address this, we used pharmacological inhibitors of the signaling proteins PI3'-kinase (LY294002), mTor (rapamycin), and MEK (PD98059, U0126, or CI-1040) either alone or in combination with one another. PDGF stimulation of quiescent NIH 3T3 cells leads to activation of both the PI3'-kinase- PDK1-AKT and the RAF-MEK-ERK signaling pathways and repression of p27Kip1 expression (Fig. 3A)." } ], "http://www.w3.org/ns/prov#wasQuotedFrom" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/15572689" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFVf4bRqu9QdH11xJE2_5lgsxLYVjY3d_-Q0efP-nRZM#_7", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "Selventa" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFVf4bRqu9QdH11xJE2_5lgsxLYVjY3d_-Q0efP-nRZM#assertion", "http://www.w3.org/ns/prov#hadPrimarySource" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/15572689" } ], "http://www.w3.org/ns/prov#wasDerivedFrom" : [ { "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel" }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFVf4bRqu9QdH11xJE2_5lgsxLYVjY3d_-Q0efP-nRZM#_6" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFVf4bRqu9QdH11xJE2_5lgsxLYVjY3d_-Q0efP-nRZM#provenance" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFVf4bRqu9QdH11xJE2_5lgsxLYVjY3d_-Q0efP-nRZM", "http://purl.org/dc/terms/created" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2014-07-03T14:30:29.937+02:00" } ], "http://purl.org/pav/createdBy" : [ { "@id" : "http://orcid.org/0000-0001-6818-334X" }, { "@id" : "http://orcid.org/0000-0002-1267-0234" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFVf4bRqu9QdH11xJE2_5lgsxLYVjY3d_-Q0efP-nRZM#pubinfo" } ]