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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAFV_IsFlJw4u-u4ZWObB8UqDujoZ-55Iy1tk_gq2a4xY#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAFV_IsFlJw4u-u4ZWObB8UqDujoZ-55Iy1tk_gq2a4xY#_5 http://www.w3.org/ns/prov#value Dexamethasone treatment decreased the ability of insulin to stimulate glucose uptake, glycogen synthesis and glycogen synthase fractional activity. In addition, the dephosphorylation of glycogen synthase by insulin was blocked. These defects were paralleled by reduced insulin-stimulated protein kinase B (PKB) and GSK-3 phosphorylation. We demonstrated that chronic dexamethasone treatment impairs insulin-stimulated PKB and GSK-3 phosphorylation, which may contribute to insulin resistance in skeletal muscles. http://www.tkuhn.ch/bel2nanopub/RAFV_IsFlJw4u-u4ZWObB8UqDujoZ-55Iy1tk_gq2a4xY#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16078016 http://www.tkuhn.ch/bel2nanopub/RAFV_IsFlJw4u-u4ZWObB8UqDujoZ-55Iy1tk_gq2a4xY#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAFV_IsFlJw4u-u4ZWObB8UqDujoZ-55Iy1tk_gq2a4xY#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16078016 http://www.tkuhn.ch/bel2nanopub/RAFV_IsFlJw4u-u4ZWObB8UqDujoZ-55Iy1tk_gq2a4xY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAFV_IsFlJw4u-u4ZWObB8UqDujoZ-55Iy1tk_gq2a4xY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAFV_IsFlJw4u-u4ZWObB8UqDujoZ-55Iy1tk_gq2a4xY#_5 http://www.tkuhn.ch/bel2nanopub/RAFV_IsFlJw4u-u4ZWObB8UqDujoZ-55Iy1tk_gq2a4xY#pubinfo http://www.tkuhn.ch/bel2nanopub/RAFV_IsFlJw4u-u4ZWObB8UqDujoZ-55Iy1tk_gq2a4xY http://purl.org/dc/terms/created 2014-07-03T14:32:48.287+02:00 http://www.tkuhn.ch/bel2nanopub/RAFV_IsFlJw4u-u4ZWObB8UqDujoZ-55Iy1tk_gq2a4xY http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAFV_IsFlJw4u-u4ZWObB8UqDujoZ-55Iy1tk_gq2a4xY http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234