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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAFTsZs9DPaD56clGhedv4pK7KnTxolCXmm8DwF77norM#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAFTsZs9DPaD56clGhedv4pK7KnTxolCXmm8DwF77norM#_4 http://www.w3.org/ns/prov#value Our previous studies showed that etoposide may induce an apoptotic signaling pathway similar to that induced by ceramide.15,16 We thus determined the generation of ceramide in etoposide-treated Jurkat T cells. Results showed that etoposide induced ceramide generation within 1 hour (Figure 4A). Treatment with fumonisin B1, an inhibitor of ceramide synthase, and myriocin, an inhibitor of serine palmitoyl transferase {SPTLC1, SPTLC2}, but not chlorpromazine and desprimine, inhibitors of acid sphingomyelinase, inhibited etoposide-induced cell apoptosis (Figure 4B), thus indicating a requirement for de novo ceramide generation. 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