. . . . . . . . . . . . . . . "a(CHEBI:etoposide) -> cat(p(HGNC:SPTLC1))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "Our previous studies showed that etoposide may induce an apoptotic signaling pathway similar to that induced by ceramide.15,16 We thus determined the generation of ceramide in etoposide-treated Jurkat T cells. Results showed that etoposide induced ceramide generation within 1 hour (Figure 4A). Treatment with fumonisin B1, an inhibitor of ceramide synthase, and myriocin, an inhibitor of serine palmitoyl transferase {SPTLC1, SPTLC2}, but not chlorpromazine and desprimine, inhibitors of acid sphingomyelinase, inhibited etoposide-induced cell apoptosis (Figure 4B), thus indicating a requirement for de novo ceramide generation. Furthermore, we demonstrated the increased expression of Txnip by etoposide (Figure 4C) " . . "Selventa" . . . . "2014-07-03T14:33:17.409+02:00"^^ . . .