. . . . . . . . . . . . . . . . . . "tscript(p(HGNC:HIF1A)) -| tscript(p(HGNC:MYC))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "Fig 3. HIF-1? counteracts Myc activity. (A) Effect of ?ODD on Myc transcriptional activity was examined with an hTERT luciferase reporter in HCT116 cells. .....Unlike wild-type HIF-1?, ?ODD constitutively activated HIF-1-mediated reporter gene in transient transfection (Figure 2A). We then inactivated ?ODD transcriptional activity via simultaneous mutations (L795V, C800S, L818S, and L822V) that disrupt p300/CBP binding (Gu et al, 2001; Dames et al, 2002; Freedman et al, 2002). As expected, this ?ODD LCLL mutant was unable to activate the HIF-1 reporter (Figure 2A)." . . "Selventa" . . . . "2014-07-03T14:32:19.741+02:00"^^ . . .