@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAFKxpGBCeVNBiUlEm5aJ9TSfysBlazEmtVfFmUz7Y9i0> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAFKxpGBCeVNBiUlEm5aJ9TSfysBlazEmtVfFmUz7Y9i0#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix scomp: <http://resource.belframework.org/belframework/20131211/namespace/selventa-named-complexes/> .
@prefix ProteinComplex: <http://amigo.geneontology.org/amigo/term/GO:0043234> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix RNA: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697> .
@prefix rgd: <http://rgd.mcw.edu/rgdweb/report/gene/main.html?id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
   scomp:AP-1%20Complex a ProteinComplex: .
  sub:_1 hasAgent: scomp:AP-1%20Complex ;
    a go:0042789 .
  sub:_2 geneProductOf: rgd:2307 ;
    a RNA: .
  sub:_3 occursIn: species:10116 ;
    rdf:object sub:_2 ;
    rdf:predicate belv:increases ;
    rdf:subject sub:_1 ;
    a rdf:Statement .
  sub:assertion rdfs:label "tscript(complex(SCOMP:\"AP-1 Complex\")) -> r(RGD:Cd44)" .
}
sub:provenance {
   beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "20131211" .
  sub:_4 prov:value "To determine the functional importance of this AP-1 site, we used site-directed mutagenesis to generate a 1.4 kb CD44 5'-promoter construct containing an AP-1 site mutation, CD44(-1,262/+109AP-1m). A comparable mutation of the AP-1 motif in the human CD44 promoter (TTAGTCA to CTAGGCA) disrupts the function of this site (53) . In comparison with the native CD44(-1,262/+109) construct, the CD44(-1,262/+109AP-1m) construct displayed a 51% reduction in promoter activity in RASMC after stimulation by IL-1ß " ;
    prov:wasQuotedFrom pubmed:10657993 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:10657993 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}
sub:pubinfo {
   this: dct:created "2014-07-03T14:31:33.841+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}