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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAFJBd5QWt9EpaFslPNGxzL0A7GW2y3ubxHiC20tQh_CQ#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAFJBd5QWt9EpaFslPNGxzL0A7GW2y3ubxHiC20tQh_CQ#_5 http://www.w3.org/ns/prov#value We currently demonstrate interactions between Shb and c-Abl and that Shb regulates c-Abl kinase activity. The data suggest that c-Abl binds to tyrosine phosphorylated Shb via a concerted effort involving both the c-Abl SH3 and SH2 domains. The biological significance of the Shb/c-Abl interaction was presently tested in overexpression experiments and was found to promote hydrogen peroxide-induced cell death. We also show by Shb knockdown experiments that Shb regulates c-Abl activity and modulates cell death in response to the genotoxic agent cisplatin and the endoplasmic reticulum stress-inducer tunicamycin. http://www.tkuhn.ch/bel2nanopub/RAFJBd5QWt9EpaFslPNGxzL0A7GW2y3ubxHiC20tQh_CQ#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17112510 http://www.tkuhn.ch/bel2nanopub/RAFJBd5QWt9EpaFslPNGxzL0A7GW2y3ubxHiC20tQh_CQ#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAFJBd5QWt9EpaFslPNGxzL0A7GW2y3ubxHiC20tQh_CQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17112510 http://www.tkuhn.ch/bel2nanopub/RAFJBd5QWt9EpaFslPNGxzL0A7GW2y3ubxHiC20tQh_CQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAFJBd5QWt9EpaFslPNGxzL0A7GW2y3ubxHiC20tQh_CQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAFJBd5QWt9EpaFslPNGxzL0A7GW2y3ubxHiC20tQh_CQ#_5 http://www.tkuhn.ch/bel2nanopub/RAFJBd5QWt9EpaFslPNGxzL0A7GW2y3ubxHiC20tQh_CQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAFJBd5QWt9EpaFslPNGxzL0A7GW2y3ubxHiC20tQh_CQ http://purl.org/dc/terms/created 2014-07-03T14:33:06.846+02:00 http://www.tkuhn.ch/bel2nanopub/RAFJBd5QWt9EpaFslPNGxzL0A7GW2y3ubxHiC20tQh_CQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAFJBd5QWt9EpaFslPNGxzL0A7GW2y3ubxHiC20tQh_CQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234