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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAFCxawGl3AEW_qo5euWBRRLQPVPhLCqiWOk0v9mfphTQ#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAFCxawGl3AEW_qo5euWBRRLQPVPhLCqiWOk0v9mfphTQ#_5 http://www.w3.org/ns/prov#value Infection of these cells with an adenoviral vector transducing the Fhit gene (Ad-Fhit) revealed that complete protection from apoptosis was conferred by the inhibitor of caspases Cytokine response modifier A (CrmA) and by a dominant-negative form of the adapter protein Fas-associated death domain (FADD) and partial protection by a dominant-negative form of caspase-8, while cells over expressing mitochondrial mediators of the apoptotic response such as Bcl-2 or Bcl-x(L) that are resistant to treatment with cisplatin, remained highly susceptible to cell death triggered by Fhit gene transfer...our analysis indicates that the Fhit protein exerts its oncosuppressor activity through induction of an apoptotic mechanism that seems to be FADD dependent, caspase-8 mediated and independent from mitochondrial amplification. http://www.tkuhn.ch/bel2nanopub/RAFCxawGl3AEW_qo5euWBRRLQPVPhLCqiWOk0v9mfphTQ#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15489891 http://www.tkuhn.ch/bel2nanopub/RAFCxawGl3AEW_qo5euWBRRLQPVPhLCqiWOk0v9mfphTQ#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAFCxawGl3AEW_qo5euWBRRLQPVPhLCqiWOk0v9mfphTQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15489891 http://www.tkuhn.ch/bel2nanopub/RAFCxawGl3AEW_qo5euWBRRLQPVPhLCqiWOk0v9mfphTQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAFCxawGl3AEW_qo5euWBRRLQPVPhLCqiWOk0v9mfphTQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAFCxawGl3AEW_qo5euWBRRLQPVPhLCqiWOk0v9mfphTQ#_5 http://www.tkuhn.ch/bel2nanopub/RAFCxawGl3AEW_qo5euWBRRLQPVPhLCqiWOk0v9mfphTQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAFCxawGl3AEW_qo5euWBRRLQPVPhLCqiWOk0v9mfphTQ http://purl.org/dc/terms/created 2014-07-03T14:32:33.532+02:00 http://www.tkuhn.ch/bel2nanopub/RAFCxawGl3AEW_qo5euWBRRLQPVPhLCqiWOk0v9mfphTQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAFCxawGl3AEW_qo5euWBRRLQPVPhLCqiWOk0v9mfphTQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234