[Evidence supporting a crucial role of environmental determinants in the pathogenesis of T1D includes: (a) the fact that <10% of those with human leukocyte antigen-conferred diabetes susceptibility progress to clinical disease; (b) a pair-wise concordance of T1D of <40% among monozygotic twins; (c) a close to 20-fold difference in the disease incidence among Caucasians living in Europe, and (d) migration studies indicating that the incidence increases in population groups who have moved from a low- to a high-incidence region.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
Gene-disease associations inferred from text-mining the literature.
DisGeNET evidence - LITERATURE