@prefix this: <http://rdf.disgenet.org/resource/nanopub/NP334771.RAF4YQWuHpxfF7iuYfTV2K3oYfDJzC-yWsYAHs-aQe8Do> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/resource/nanopub/> .
@prefix dgn-gda: <http://rdf.disgenet.org/resource/gda/> .
@prefix dgn-void: <http://rdf.disgenet.org/v4.0.0/void/> .

dgn-np:NP334771.RAF4YQWuHpxfF7iuYfTV2K3oYfDJzC-yWsYAHs-aQe8Do130_head {
  this: np:hasAssertion dgn-np:NP334771.RAF4YQWuHpxfF7iuYfTV2K3oYfDJzC-yWsYAHs-aQe8Do130_assertion;
    np:hasProvenance dgn-np:NP334771.RAF4YQWuHpxfF7iuYfTV2K3oYfDJzC-yWsYAHs-aQe8Do130_provenance;
    np:hasPublicationInfo dgn-np:NP334771.RAF4YQWuHpxfF7iuYfTV2K3oYfDJzC-yWsYAHs-aQe8Do130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP334771.RAF4YQWuHpxfF7iuYfTV2K3oYfDJzC-yWsYAHs-aQe8Do130_assertion a np:Assertion .
  
  dgn-np:NP334771.RAF4YQWuHpxfF7iuYfTV2K3oYfDJzC-yWsYAHs-aQe8Do130_provenance a np:Provenance .
  
  dgn-np:NP334771.RAF4YQWuHpxfF7iuYfTV2K3oYfDJzC-yWsYAHs-aQe8Do130_publicationInfo a
      np:PublicationInfo .
}

dgn-np:NP334771.RAF4YQWuHpxfF7iuYfTV2K3oYfDJzC-yWsYAHs-aQe8Do130_assertion {
  miriam-gene:5743 a ncit:C16612 .
  
  lld:C0374997 a ncit:C7057 .
  
  dgn-gda:DGNcf52326ebd8cdc268e7c5006f60fbf59 sio:SIO_000628 miriam-gene:5743, lld:C0374997;
    a sio:SIO_001121 .
}

dgn-np:NP334771.RAF4YQWuHpxfF7iuYfTV2K3oYfDJzC-yWsYAHs-aQe8Do130_provenance {
  dgn-np:NP334771.RAF4YQWuHpxfF7iuYfTV2K3oYfDJzC-yWsYAHs-aQe8Do130_assertion dcterms:description
      "[1) Colorectal carcinoma and its resection margin overexpress gastrin and receptors for gastrin (CCK(B)-R), and COX-2; 2) here, we propose that an increased plasma level of gastrin should be considered as suitable biomarker of colorectal cancer, 3) HP infection may contribute to colonic cancerogenesis by enhancing expression of gastrin and COX-2, they may account for stimulation of the tumor growth, angiogenesis and reduction in apoptosis as evidenced an increased ratio of mRNA expression for anti-apoptotic Bcl2 over proapoptotic Bax proteins and 4) HP positive patients who develop colorectal cancer should be subjected to the HP eradication; this is expected to reduce hypergastrinemia and to attenuate COX-2 expression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:11687726;
    prov:wasDerivedFrom dgn-void:befree-2016;
    prov:wasGeneratedBy eco:ECO_0000203 .
  
  dgn-void:befree-2016 pav:importedOn "2016-02-19"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP334771.RAF4YQWuHpxfF7iuYfTV2K3oYfDJzC-yWsYAHs-aQe8Do130_publicationInfo {
  this: dcterms:created "2016-05-13T12:44:17+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetv3.0rdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
    pav:createdBy <http://orcid.org/0000-0003-0169-8159>;
    pav:version "v4.0.0.0" .
  
  dgn-void:disgenetv3.0rdf pav:version "v4.0.0" .
}