http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#Head http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0 http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#assertion http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0 http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#provenance http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0 http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#pubinfo http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#assertion http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:109392 http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#_1 http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.ebi.ac.uk/chebi/searchId.do?chebiId=23965 http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#assertion http://www.w3.org/2000/01/rdf-schema#label a(CHEBI:estradiol) -> p(MGI:Esr2) http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#_3 http://www.w3.org/ns/prov#value Incubation with estradiol (E2) decreased the synthesis of type IV collagen (61.6 and 71.9 % of control for 0.1 and 1 nmol/l of E2, respectively) in B6 aortic smooth muscle cell layers (ASMCs) but not in C3H-ASMC layers. But treatment with estrogen receptor antagonist ICI, abolished the E2-induced decrease in type IV collagen synthesis in B6-ASMCs (1 micromol/l, 110.5 and 114.3 % of control in the cell layer and supernatant, respectively), whereas ICI alone had no effect. Furthermore, the ER transcriptional activity was higher in B6-ASMCs than in C3H-ASMCs. Treatment of luciferase based reporter plasmid with ER transfected B6-ASMCs with 1nM E2 increased the luciferase activity by 2.2-fold. This indicates that estradiol induced type IV collagen synthesis was mediated by estrogen receptor beta. http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12915398 http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12915398 http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#_3 http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#pubinfo http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0 http://purl.org/dc/terms/created 2014-07-03T14:30:15.491+02:00 http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234