[ {
  "@graph" : [ {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0",
    "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ],
    "http://www.nanopub.org/nschema#hasAssertion" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#assertion"
    } ],
    "http://www.nanopub.org/nschema#hasProvenance" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#provenance"
    } ],
    "http://www.nanopub.org/nschema#hasPublicationInfo" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#pubinfo"
    } ]
  } ],
  "@id" : "http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#Head"
}, {
  "@graph" : [ {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#_1",
    "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ],
    "http://purl.obolibrary.org/obo/RO_0002204" : [ {
      "@id" : "http://www.informatics.jax.org/marker/MGI:109392"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#_2",
    "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ],
    "http://purl.obolibrary.org/obo/BFO_0000066" : [ {
      "@id" : "http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#_1"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ {
      "@id" : "http://www.selventa.com/vocabulary/increases"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ {
      "@id" : "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=23965"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#assertion",
    "http://www.w3.org/2000/01/rdf-schema#label" : [ {
      "@value" : "a(CHEBI:estradiol) -> p(MGI:Esr2)"
    } ]
  } ],
  "@id" : "http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#assertion"
}, {
  "@graph" : [ {
    "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel",
    "http://purl.org/dc/elements/1.1/description" : [ {
      "@value" : "Approximately 61,000 statements."
    } ],
    "http://purl.org/dc/elements/1.1/rights" : [ {
      "@value" : "Copyright (c) 2011-2012, Selventa. All rights reserved."
    } ],
    "http://purl.org/dc/elements/1.1/title" : [ {
      "@value" : "BEL Framework Large Corpus Document"
    } ],
    "http://purl.org/pav/authoredBy" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#_4"
    } ],
    "http://purl.org/pav/version" : [ {
      "@value" : "1.4"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#_3",
    "http://www.w3.org/ns/prov#value" : [ {
      "@value" : "Incubation with estradiol (E2) decreased the synthesis of type IV collagen (61.6 and 71.9 % of control for 0.1 and 1 nmol/l of E2, respectively) in B6 aortic smooth muscle cell layers (ASMCs) but not in C3H-ASMC layers. But treatment with estrogen receptor antagonist ICI, abolished the E2-induced decrease in type IV collagen synthesis in B6-ASMCs (1 micromol/l, 110.5 and 114.3 % of control in the cell layer and supernatant, respectively), whereas ICI alone had no effect. Furthermore, the ER transcriptional activity was higher in B6-ASMCs than in C3H-ASMCs. Treatment of luciferase based reporter plasmid with ER transfected B6-ASMCs with 1nM E2 increased the luciferase activity by 2.2-fold. This indicates that estradiol induced type IV collagen synthesis was mediated by estrogen receptor beta."
    } ],
    "http://www.w3.org/ns/prov#wasQuotedFrom" : [ {
      "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/12915398"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#_4",
    "http://www.w3.org/2000/01/rdf-schema#label" : [ {
      "@value" : "Selventa"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#assertion",
    "http://www.w3.org/ns/prov#hadPrimarySource" : [ {
      "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/12915398"
    } ],
    "http://www.w3.org/ns/prov#wasDerivedFrom" : [ {
      "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel"
    }, {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#_3"
    } ]
  } ],
  "@id" : "http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#provenance"
}, {
  "@graph" : [ {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0",
    "http://purl.org/dc/terms/created" : [ {
      "@type" : "http://www.w3.org/2001/XMLSchema#dateTime",
      "@value" : "2014-07-03T14:30:15.491+02:00"
    } ],
    "http://purl.org/pav/createdBy" : [ {
      "@id" : "http://orcid.org/0000-0001-6818-334X"
    }, {
      "@id" : "http://orcid.org/0000-0002-1267-0234"
    } ]
  } ],
  "@id" : "http://www.tkuhn.ch/bel2nanopub/RAF2njcjsHo6_veQf2VIVuuYqSGFcr5TX5msiyIv-8Cg0#pubinfo"
} ]