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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAElaX19tWulTS8RKgmfUNaz5nFWN7tXkUmw0A6WY8kn8#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAElaX19tWulTS8RKgmfUNaz5nFWN7tXkUmw0A6WY8kn8#_5 http://www.w3.org/ns/prov#value Repression of these SMC1{beta} promoter constructs by E2F6 was confirmed by inhibition of reporter gene expression by overexpressed E2F6 (Fig. 2C). A point mutant of E2F6 defective in DNA binding (E68) (6) had no effect on reporter gene expression, demonstrating that repression of SMC1{beta} by E2F6 depends on sequence-specific DNA-binding. The -26 promoter had equal activity in wild-type and E2f6-/- cells and was not repressed by the coexpression of E2F6. This finding suggests that an E2F6-responsive site is located between nucleotides -26 and -129 of the SMC1{beta} promoter. Examination of this part of the promoter sequence showed that it contains a potential E2F binding site (see Fig. 2D). To test whether this E2F site is required for repression of the SMC1{beta} promoter by E2F6, we mutated the E2F element and analyzed the activity of the mutated reporter construct in E2f6+/+ and E2f6-/- cells (Fig. 2E). The mutated reporter gene had equal activity in E2f6+/+ and E2f6-/- cells, demonstrating that the E2F site is required for repression by E2F6. http://www.tkuhn.ch/bel2nanopub/RAElaX19tWulTS8RKgmfUNaz5nFWN7tXkUmw0A6WY8kn8#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16236716 http://www.tkuhn.ch/bel2nanopub/RAElaX19tWulTS8RKgmfUNaz5nFWN7tXkUmw0A6WY8kn8#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAElaX19tWulTS8RKgmfUNaz5nFWN7tXkUmw0A6WY8kn8#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16236716 http://www.tkuhn.ch/bel2nanopub/RAElaX19tWulTS8RKgmfUNaz5nFWN7tXkUmw0A6WY8kn8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAElaX19tWulTS8RKgmfUNaz5nFWN7tXkUmw0A6WY8kn8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAElaX19tWulTS8RKgmfUNaz5nFWN7tXkUmw0A6WY8kn8#_5 http://www.tkuhn.ch/bel2nanopub/RAElaX19tWulTS8RKgmfUNaz5nFWN7tXkUmw0A6WY8kn8#pubinfo http://www.tkuhn.ch/bel2nanopub/RAElaX19tWulTS8RKgmfUNaz5nFWN7tXkUmw0A6WY8kn8 http://purl.org/dc/terms/created 2014-07-03T14:32:51.589+02:00 http://www.tkuhn.ch/bel2nanopub/RAElaX19tWulTS8RKgmfUNaz5nFWN7tXkUmw0A6WY8kn8 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAElaX19tWulTS8RKgmfUNaz5nFWN7tXkUmw0A6WY8kn8 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234