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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAEfVRbAr5p5EW61tgw2DzflwnKmO0ocVtqvmS3IN7_rw#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAEfVRbAr5p5EW61tgw2DzflwnKmO0ocVtqvmS3IN7_rw#_5 http://www.w3.org/ns/prov#value The ERK2 MAP kinase pathway controls cell growth and survival and modulates integrin function. Here, we report that PEA15, a protein variably expressed in multiple cell types, blocks ERK-dependent transcription and proliferation by binding ERKs and preventing their localization in the nucleus. PEA-15 contains a nuclear export sequence required for its capacity to anchor ERK in the cytoplasm. Genetic deletion of PEA-15 results in increased ERK nuclear localization with consequent increased cFos transcription and cell proliferation. Thus, PEA-15 can redirect the biological outcome of MAP kinase signaling by regulating the subcellular localization of ERK MAP kinase. http://www.tkuhn.ch/bel2nanopub/RAEfVRbAr5p5EW61tgw2DzflwnKmO0ocVtqvmS3IN7_rw#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11702783 http://www.tkuhn.ch/bel2nanopub/RAEfVRbAr5p5EW61tgw2DzflwnKmO0ocVtqvmS3IN7_rw#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAEfVRbAr5p5EW61tgw2DzflwnKmO0ocVtqvmS3IN7_rw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11702783 http://www.tkuhn.ch/bel2nanopub/RAEfVRbAr5p5EW61tgw2DzflwnKmO0ocVtqvmS3IN7_rw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAEfVRbAr5p5EW61tgw2DzflwnKmO0ocVtqvmS3IN7_rw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAEfVRbAr5p5EW61tgw2DzflwnKmO0ocVtqvmS3IN7_rw#_5 http://www.tkuhn.ch/bel2nanopub/RAEfVRbAr5p5EW61tgw2DzflwnKmO0ocVtqvmS3IN7_rw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAEfVRbAr5p5EW61tgw2DzflwnKmO0ocVtqvmS3IN7_rw http://purl.org/dc/terms/created 2014-07-03T14:31:44.600+02:00 http://www.tkuhn.ch/bel2nanopub/RAEfVRbAr5p5EW61tgw2DzflwnKmO0ocVtqvmS3IN7_rw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAEfVRbAr5p5EW61tgw2DzflwnKmO0ocVtqvmS3IN7_rw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234