. . . . . . . . . . . . . . . "p(HGNC:PEA15) -| tscript(p(HGNC:FOS))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "The ERK2 MAP kinase pathway controls cell growth and survival and modulates integrin function. Here, we report that PEA15, a protein variably expressed in multiple cell types, blocks ERK-dependent transcription and proliferation by binding ERKs and preventing their localization in the nucleus. PEA-15 contains a nuclear export sequence required for its capacity to anchor ERK in the cytoplasm. Genetic deletion of PEA-15 results in increased ERK nuclear localization with consequent increased cFos transcription and cell proliferation. Thus, PEA-15 can redirect the biological outcome of MAP kinase signaling by regulating the subcellular localization of ERK MAP kinase." . . "Selventa" . . . . "2014-07-03T14:31:44.600+02:00"^^ . . .