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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAEfFRh8iqlW1TQkkNRmUez1Iex5UJiazyOkttmh5CQn0#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAEfFRh8iqlW1TQkkNRmUez1Iex5UJiazyOkttmh5CQn0#_5 http://www.w3.org/ns/prov#value The POU IV family members are the closest mammalian homologs to the nematode Unc-86. This, together with their restricted expression in the developing and adult nervous system, has led to the idea that they may play a role in regulating gene expression in neuronal cells. SNAP-25 is a presynaptic nerve terminal protein, and its promoter has been shown to be activated by POU4F3 only in neuron-derived cell lines such as PC12 and ND7. This activation depends on a neuron-specific activation domain in the amino terminus of POU4F3 (30). PC12 cells transfected with the pHM6 vector, pHM6-wt (wild-type POU4F3 cDNA), or pHM6-mut (del8 POU4F3 cDNA) constructs were examined for their ability to activate the SNAP-25 promoter connected to a luciferase reporter gene. The luciferase values were normalized for ß-galactosidase levels. We found that the mutant product had only ca. 30% activity compared to the wild-type product [(1.3 ± 0.07)-fold versus (2.02 ± 0.06)-fold] http://www.tkuhn.ch/bel2nanopub/RAEfFRh8iqlW1TQkkNRmUez1Iex5UJiazyOkttmh5CQn0#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14585957 http://www.tkuhn.ch/bel2nanopub/RAEfFRh8iqlW1TQkkNRmUez1Iex5UJiazyOkttmh5CQn0#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAEfFRh8iqlW1TQkkNRmUez1Iex5UJiazyOkttmh5CQn0#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14585957 http://www.tkuhn.ch/bel2nanopub/RAEfFRh8iqlW1TQkkNRmUez1Iex5UJiazyOkttmh5CQn0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAEfFRh8iqlW1TQkkNRmUez1Iex5UJiazyOkttmh5CQn0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAEfFRh8iqlW1TQkkNRmUez1Iex5UJiazyOkttmh5CQn0#_5 http://www.tkuhn.ch/bel2nanopub/RAEfFRh8iqlW1TQkkNRmUez1Iex5UJiazyOkttmh5CQn0#pubinfo http://www.tkuhn.ch/bel2nanopub/RAEfFRh8iqlW1TQkkNRmUez1Iex5UJiazyOkttmh5CQn0 http://purl.org/dc/terms/created 2014-07-03T14:32:10.849+02:00 http://www.tkuhn.ch/bel2nanopub/RAEfFRh8iqlW1TQkkNRmUez1Iex5UJiazyOkttmh5CQn0 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAEfFRh8iqlW1TQkkNRmUez1Iex5UJiazyOkttmh5CQn0 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234