@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAEfFRh8iqlW1TQkkNRmUez1Iex5UJiazyOkttmh5CQn0> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAEfFRh8iqlW1TQkkNRmUez1Iex5UJiazyOkttmh5CQn0#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix rgd: <http://rgd.mcw.edu/rgdweb/report/gene/main.html?id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix RNA: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasAgent: sub:_2;
    a go:0042789 .
  
  sub:_2 geneProductOf: rgd:1310459;
    a Protein: .
  
  sub:_3 geneProductOf: rgd:3728;
    a RNA: .
  
  sub:_4 occursIn: obo:CLO_0008392, species:10116;
    rdf:object sub:_3;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "tscript(p(RGD:Pou4f3)) -> r(RGD:Snap25)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_6;
    pav:version "20131211" .
  
  sub:_5 prov:value "The POU IV family members are the closest mammalian homologs to the nematode Unc-86. This, together with their restricted expression in the developing and adult nervous system, has led to the idea that they may play a role in regulating gene expression in neuronal cells. SNAP-25 is a presynaptic nerve terminal protein, and its promoter has been shown to be activated by POU4F3 only in neuron-derived cell lines such as PC12 and ND7. This activation depends on a neuron-specific activation domain in the amino terminus of POU4F3 (30). PC12 cells transfected with the pHM6 vector, pHM6-wt (wild-type POU4F3 cDNA), or pHM6-mut (del8 POU4F3 cDNA) constructs were examined for their ability to activate the SNAP-25 promoter connected to a luciferase reporter gene. The luciferase values were normalized for ß-galactosidase levels. We found that the mutant product had only ca. 30% activity compared to the wild-type product [(1.3 ± 0.07)-fold versus (2.02 ± 0.06)-fold] ";
    prov:wasQuotedFrom pubmed:14585957 .
  
  sub:_6 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:14585957;
    prov:wasDerivedFrom beldoc:, sub:_5 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:32:10.849+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}