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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAEcVNrl4t9Lmi23SUz2g08e-57xLBcd3_5RbC7Z4KHP0#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAEcVNrl4t9Lmi23SUz2g08e-57xLBcd3_5RbC7Z4KHP0#_6 http://www.w3.org/ns/prov#value We found that CBS-deficiency in liver mice significantly increases expression of genes induced by endoplasmic reticulum stress and genes that regulate the expression of enzymes required for cholesterol and fatty acid biosynthesis and uptake, notably the scavenger receptor class B type I (SR-BI), concomitant with overexpression of SR-BI at the protein level. Moreover, we also found increased mRNA levels of ABCG5, ABCG8, ABCG1 and ABCA1, which play important roles in reverse cholesterol transport, associated with an upregulation of liver X receptors and a downregulation of the peroxisome proliferators-activated receptor alpha. http://www.tkuhn.ch/bel2nanopub/RAEcVNrl4t9Lmi23SUz2g08e-57xLBcd3_5RbC7Z4KHP0#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17030070 http://www.tkuhn.ch/bel2nanopub/RAEcVNrl4t9Lmi23SUz2g08e-57xLBcd3_5RbC7Z4KHP0#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAEcVNrl4t9Lmi23SUz2g08e-57xLBcd3_5RbC7Z4KHP0#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17030070 http://www.tkuhn.ch/bel2nanopub/RAEcVNrl4t9Lmi23SUz2g08e-57xLBcd3_5RbC7Z4KHP0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAEcVNrl4t9Lmi23SUz2g08e-57xLBcd3_5RbC7Z4KHP0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAEcVNrl4t9Lmi23SUz2g08e-57xLBcd3_5RbC7Z4KHP0#_6 http://www.tkuhn.ch/bel2nanopub/RAEcVNrl4t9Lmi23SUz2g08e-57xLBcd3_5RbC7Z4KHP0#pubinfo http://www.tkuhn.ch/bel2nanopub/RAEcVNrl4t9Lmi23SUz2g08e-57xLBcd3_5RbC7Z4KHP0 http://purl.org/dc/terms/created 2014-07-03T14:33:04.421+02:00 http://www.tkuhn.ch/bel2nanopub/RAEcVNrl4t9Lmi23SUz2g08e-57xLBcd3_5RbC7Z4KHP0 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAEcVNrl4t9Lmi23SUz2g08e-57xLBcd3_5RbC7Z4KHP0 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234