@prefix this: <http://rdf.disgenet.org/resource/nanopub/NP999229.RAEYXM6_rODK5XVqKFTYu34lqJNNu5L21bZdmTdBmZwJ0> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/resource/nanopub/> .
@prefix dgn-gda: <http://rdf.disgenet.org/resource/gda/> .
@prefix dgn-void: <http://rdf.disgenet.org/v4.0.0/void/> .

dgn-np:NP999229.RAEYXM6_rODK5XVqKFTYu34lqJNNu5L21bZdmTdBmZwJ0130_head {
  this: np:hasAssertion dgn-np:NP999229.RAEYXM6_rODK5XVqKFTYu34lqJNNu5L21bZdmTdBmZwJ0130_assertion;
    np:hasProvenance dgn-np:NP999229.RAEYXM6_rODK5XVqKFTYu34lqJNNu5L21bZdmTdBmZwJ0130_provenance;
    np:hasPublicationInfo dgn-np:NP999229.RAEYXM6_rODK5XVqKFTYu34lqJNNu5L21bZdmTdBmZwJ0130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP999229.RAEYXM6_rODK5XVqKFTYu34lqJNNu5L21bZdmTdBmZwJ0130_assertion a np:Assertion .
  
  dgn-np:NP999229.RAEYXM6_rODK5XVqKFTYu34lqJNNu5L21bZdmTdBmZwJ0130_provenance a np:Provenance .
  
  dgn-np:NP999229.RAEYXM6_rODK5XVqKFTYu34lqJNNu5L21bZdmTdBmZwJ0130_publicationInfo a
      np:PublicationInfo .
}

dgn-np:NP999229.RAEYXM6_rODK5XVqKFTYu34lqJNNu5L21bZdmTdBmZwJ0130_assertion {
  miriam-gene:5728 a ncit:C16612 .
  
  lld:C0006142 a ncit:C7057 .
  
  dgn-gda:DGNc5c8b298ce074a3d6eb3b3fc7993ec30 sio:SIO_000628 miriam-gene:5728, lld:C0006142;
    a sio:SIO_001121 .
}

dgn-np:NP999229.RAEYXM6_rODK5XVqKFTYu34lqJNNu5L21bZdmTdBmZwJ0130_provenance {
  dgn-np:NP999229.RAEYXM6_rODK5XVqKFTYu34lqJNNu5L21bZdmTdBmZwJ0130_assertion dcterms:description
      "[We generated trastuzumab resistant cells by knocking down PTEN expression in HER2 overexpressing breast cancer cell lines and demonstrate that development of trastuzumab resistance in these cells is mediated by activation of an IL6 inflammatory feedback loop leading to expansion of the cancer stem cell (CSC) population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:22819326;
    prov:wasDerivedFrom dgn-void:befree-2016;
    prov:wasGeneratedBy eco:ECO_0000203 .
  
  dgn-void:befree-2016 pav:importedOn "2016-02-19"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP999229.RAEYXM6_rODK5XVqKFTYu34lqJNNu5L21bZdmTdBmZwJ0130_publicationInfo {
  this: dcterms:created "2016-05-13T12:49:18+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetv3.0rdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
    pav:createdBy <http://orcid.org/0000-0003-0169-8159>;
    pav:version "v4.0.0.0" .
  
  dgn-void:disgenetv3.0rdf pav:version "v4.0.0" .
}