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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAEVdY3t5ICSbj9b2sHwANtAuAOL7r0DYP0FhPSa4xXMk#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAEVdY3t5ICSbj9b2sHwANtAuAOL7r0DYP0FhPSa4xXMk#_5 http://www.w3.org/ns/prov#value <E25> Sp1 and E2F binding sites are both essential for activation of the murine thymidine kinase promoter (Karlseder et al., 1996). The promoter was activated when the Sp1 and E2F sites were separated by 6 or 10 bp but not when they were separated by 20 bp. The DHFR promoter was strongly activated by Sp1 alone but hardly at all by E2F1 alone (cotransfection in insect cells) (Lin et al., 1996a). 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