sub:assertion {
  sub:_1 sio:SIO_000053 sub:_2 , sub:_3 ;
    a so:SO_0001148 , range:RangedSequencePosition ;
    rdfs:comment "Reduced dimerization in neutral pH. Eliminates the pH dependence of dimerization." .
  sub:_10 sio:SIO_000053 sub:_11 , sub:_12 ;
    a so:SO_0001148 , range:RangedSequencePosition ;
    rdfs:comment "No effect on CXCR4 activation. Impaired dimer formation, leading to increased chemotactic activity. Eliminates the pH dependence of dimerization." .
  sub:_11 sio:SIO_000300 46 ;
    a range:StartPosition .
  sub:_12 sio:SIO_000300 46 ;
    a range:EndPosition .
  sub:_2 sio:SIO_000300 46 ;
    a range:StartPosition .
  sub:_3 sio:SIO_000300 46 ;
    a range:EndPosition .
  sub:_4 sio:SIO_000053 sub:_5 , sub:_6 ;
    a so:SO_0001148 , range:RangedSequencePosition ;
    rdfs:comment "No significant effect on dimerization in neutral pH. Eliminates the pH dependence of dimerization." .
  sub:_5 sio:SIO_000300 46 ;
    a range:StartPosition .
  sub:_6 sio:SIO_000300 46 ;
    a range:EndPosition .
  sub:_7 sio:SIO_000053 sub:_8 , sub:_9 ;
    a so:SO_0001148 , range:RangedSequencePosition ;
    rdfs:comment "Slightly impaired CXCR4 activation and clear resistance to inhibition by heparin; when associated with Q-48; Q-62; Q-68 and N-69." .
  sub:_8 sio:SIO_000300 46 ;
    a range:StartPosition .
  sub:_9 sio:SIO_000300 46 ;
    a range:EndPosition .
  sub:assertion rdfs:comment "Mutagenesis site occurs in NX_P48061-6 at amino acids 46 - 46." .
  sub:seqFeature bfo:BFO_0000066 nx:NX_P48061-6 ;
    sio:SIO_000008 sub:_1 , sub:_10 , sub:_4 , sub:_7 ;
    a so:SO_000010 .
}