@prefix this: <http://www.tkuhn.ch/bel2nanopub/RADrjuXr7JhocSxqiLcjG5FZTlolo2E2fMEkhnQ2uTPsU> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RADrjuXr7JhocSxqiLcjG5FZTlolo2E2fMEkhnQ2uTPsU#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix RNA: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697> .
@prefix entrez: <http://www.ncbi.nlm.nih.gov/gene/> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: entrez:55818;
    a RNA: .
  
  sub:_2 occursIn: obo:CL_0000115, obo:UBERON_0000948, species:9606;
    rdf:object sub:_1;
    rdf:predicate belv:increases;
    rdf:subject go:0001666;
    a rdf:Statement .
  
  sub:assertion rdfs:label "bp(GOBP:\"response to hypoxia\") -> r(EGID:55818)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_4;
    pav:version "20131211" .
  
  sub:_3 prov:value "Human microvascular endothelial cells from lung (HMVEC-Lung, HMVEC-L) and cardiac (HMVEC-Cardiac, HMVEC-C) cells were cultured and exposed to hypoxia (1% O2, 5% CO2, and 94% N2) on 6 separate occasions, and total RNA was extracted. Experimental samples (n = 3) were formed by randomly pooling RNA from 2 independent experiments. This process was repeated at each of 4 experimental time points yielding 12 separate arrays for lung and cardiac experiments. Affymetrix GeneChip Human Genome U133A chips, which allow the simultaneous analysis of 22,283 gene transcripts, were used. * Genstruct R-pipeline analysis of GSE11341 conducted Nov 2010 by DD.  Cutoffs for curation applied by AV were FC>1.5 and adj. p<.01. The 48h treatment timepoint was selected for curation because, as the paper reports, \\\"An incremental increase in the expression of 2 well-characterized hypoxia-responsive marker genes, namely VEGF-A and solute carrier family 2 member 1 [SLC2A1 (previously called GLUT1)], was measured by RT-PCR.\\\"";
    prov:wasQuotedFrom pubmed:18469115 .
  
  sub:_4 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:18469115;
    prov:wasDerivedFrom beldoc:, sub:_3 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:33:21.260+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}