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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RADrgSWaW0P5ffxJJbM99x04xl-EVzdx29gRSyLf1KCeY#_8 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RADrgSWaW0P5ffxJJbM99x04xl-EVzdx29gRSyLf1KCeY#_7 http://www.w3.org/ns/prov#value from full text - In BE cells transfected with b-arrestin1 siRNA no pERK signals were detected (Fig. 1, C and D). These data provide further evidence that b-arrestin1 is necessary for IGF-1-induced ERK activation. We also investigated whether b-arrestin2 played a similar role. However, no significant reduction in IGF-1-stimulated pERK was observed in BE cells transfected with b-arrestin2 siRNA (Fig. 1, C and D). 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