sub:provenance { beldoc:dce:description "Approximately 61,000 statements." ; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ; dce:title "BEL Framework Large Corpus Document" ; pav:authoredBysub:_8 ; pav:version "20131211" . sub:_7prov:value "from full text - In BE cells transfected with b-arrestin1 siRNA no pERK signals were detected (Fig. 1, C and D). These data provide further evidence that b-arrestin1 is necessary for IGF-1-induced ERK activation. We also investigated whether b-arrestin2 played a similar role. However, no significant reduction in IGF-1-stimulated pERK was observed in BE cells transfected with b-arrestin2 siRNA (Fig. 1, C and D). In contrast, down-regulation of b-arrestin2 levels led to an increase in both basal and IGF-1-stimulated ERK activity that was sustained up to 60 min (Fig. 1, C and D)." ; prov:wasQuotedFrompubmed:17303558 . sub:_8rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcepubmed:17303558 ; prov:wasDerivedFrombeldoc: , sub:_7 . }