@prefix this: <http://www.tkuhn.ch/bel2nanopub/RADljVgEg0yboShf1onrguurYSEm2PAXnw7jmQDTyWFQU> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RADljVgEg0yboShf1onrguurYSEm2PAXnw7jmQDTyWFQU#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix chebi: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=> .
@prefix RNA: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: hgnc:3778;
    a RNA: .
  
  sub:_2 occursIn: obo:CL_0002518, obo:UBERON_0002113, species:9606;
    rdf:object sub:_1;
    rdf:predicate belv:increases;
    rdf:subject chebi:5586;
    a rdf:Statement .
  
  sub:assertion rdfs:label "a(CHEBI:\"hydrogen peroxide\") -> r(HGNC:FN1)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_4;
    pav:version "20131211" .
  
  sub:_3 prov:value "Both high glucose and ROS activate signal transduction cascade (PKC, mitogen- activated protein kinases,and janus kinase/signal transducers and activators of transcription) and transcription factors (nuclear factor-kappaB, activated protein-1, and specificity protein 1) and upregulate TGF-beta1 and ECM genes and proteins. High glucose induces reactive oxygen species (ROS) (3,4) and upregulates TGF-b1 (5,6) and ECM (5-7) expression in the glomerular mesangial cells. Exogenous hydrogen peroxide (H2O2) or H2O2 continuously generated by glucose oxidase (GO) also upregulates TGF-b1 and fibronectin expression in mesangial cells (4,8) and fibronectin in tubular epithelial cells";
    prov:wasQuotedFrom pubmed:12874439 .
  
  sub:_4 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:12874439;
    prov:wasDerivedFrom beldoc:, sub:_3 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:32:04.951+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}