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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RADkEk21L6BdkphI_u09Uz2ix5kkMFK6Xt2fr838S053A#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RADkEk21L6BdkphI_u09Uz2ix5kkMFK6Xt2fr838S053A#_5 http://www.w3.org/ns/prov#value The human interstitial collagenase (MMP-1) promoter has been also shown to be a Ras-responsive promoter by virtue of the presence of ETS and AP-1 cis-elements, which act synergistically to activate Ras-dependent transcription of the gene (15, 16). Similarly to what was observed previously with the synthetic ORE reporter, ESE-3 was able to repress the -1200 to +63 collagenase promoter response to Ras (Fig. 6B). 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