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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RADfD0npUYztvg4TnXLcwVqmnKwbaw7DfxAwdWDb8Rq84#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RADfD0npUYztvg4TnXLcwVqmnKwbaw7DfxAwdWDb8Rq84#_3 http://www.w3.org/ns/prov#value Chung (48, 49) summarized in detail the cytokines overexpressed in COPD (48, 49). IL-6, IL-1beta, TNF-{alpha}, growth-related gene-{alpha} (Gro-{alpha})/keratinocyte-derived chemokine (KC) (CXCL1), monocyte chemoattractant protein-1 (MCP-1), and IL-8 were increased in sputum, with further increases during exacerbations of COPD, and the bronchiolar epithelium overexpressed MCP-1, its receptor CCR2, MIP1{alpha}, and IL-8. MCP-1 and CCR2 were involved in the recruitment of macrophages and mast cells into the airway epithelium in COPD (62). http://www.tkuhn.ch/bel2nanopub/RADfD0npUYztvg4TnXLcwVqmnKwbaw7DfxAwdWDb8Rq84#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17615396 http://www.tkuhn.ch/bel2nanopub/RADfD0npUYztvg4TnXLcwVqmnKwbaw7DfxAwdWDb8Rq84#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RADfD0npUYztvg4TnXLcwVqmnKwbaw7DfxAwdWDb8Rq84#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17615396 http://www.tkuhn.ch/bel2nanopub/RADfD0npUYztvg4TnXLcwVqmnKwbaw7DfxAwdWDb8Rq84#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RADfD0npUYztvg4TnXLcwVqmnKwbaw7DfxAwdWDb8Rq84#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RADfD0npUYztvg4TnXLcwVqmnKwbaw7DfxAwdWDb8Rq84#_3 http://www.tkuhn.ch/bel2nanopub/RADfD0npUYztvg4TnXLcwVqmnKwbaw7DfxAwdWDb8Rq84#pubinfo http://www.tkuhn.ch/bel2nanopub/RADfD0npUYztvg4TnXLcwVqmnKwbaw7DfxAwdWDb8Rq84 http://purl.org/dc/terms/created 2014-07-03T14:30:51.191+02:00 http://www.tkuhn.ch/bel2nanopub/RADfD0npUYztvg4TnXLcwVqmnKwbaw7DfxAwdWDb8Rq84 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RADfD0npUYztvg4TnXLcwVqmnKwbaw7DfxAwdWDb8Rq84 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234