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cat(p(HGNC:TNFRSF1A)) -> bp(MESHPP:Apoptosis)
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Approximately 61,000 statements.
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GSK-3b activity restrains pro-apoptotic signaling from death receptors (ie, TNF-R1 {Official Gene Symbol: TNFRSF1A}, Fas, DR4 {Official Gene Symbol: TNFRSF10A}, DR5 {Official Gene Symbol: TNFRSF10B}).77?80 Inhibition of GSK-3b in the cells with activated death receptors enhanced activation of caspases-8 and -3, Bid cleavage and apoptosis, indicating that GSK-3b suppresses pro-apoptotic signals upstream of caspase activation.78?80 Thus, inactivation of GSK-3b under the condition of stimulation of death receptors promotes apoptosis.
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