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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#_4 http://www.w3.org/ns/prov#value In c-MET-overexpressing SCLC cell line NCI-H69, hepatocyte growth factor (HGF) dramatically induced c-MET phosphorylation at phosphoepitopes pY1230/1234/1235 (catalytic tyrosine kinase), pY1003 (juxtamembrane), and also of paxillin at pY31 (CRKL-binding site). We utilised a global proteomics phosphoantibody array approach to identify further c-MET/HGF signal transduction intermediates in SCLC. Strong HGF induction of specific phosphorylation sites in phosphoproteins involved in c-MET/HGF signal transduction was detected, namely adducin-alpha [S724], adducin-gamma [S662], CREB [S133], ERK1 [T185/Y187], ERK1/2 [T202/Y204], ERK2 [T185/Y187], MAPKK (MEK) 1/2 [S221/S225], MAPKK (MEK) 3/6 [S189/S207], RB [S612], RB1 [S780], JNK [T183/Y185], STAT3 [S727], focal adhesion kinase (FAK) [Y576/S722/S910], p38alpha-MAPK [T180/Y182], and AKT1[S473] and [T308]. Conversely, we also identified modest inhibition of phosphorylation by HGF in the following phosphoproteins (Figures 2A and B): PKCa [S657], PKCa/b [T368/641], and PKCd [T505]. Moreover, HGF also inhibited phosphorylation of PKR [T451], which is known to have antiproliferative and pro-apoptotic functions. Lastly, HGF also reduced the threonine and tyrosine phosphorylation of the cell cycle checkpoint regulator CDK1 [T14/Y15]. http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17667909 http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17667909 http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#_4 http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#pubinfo http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE http://purl.org/dc/terms/created 2014-07-03T14:33:12.105+02:00 http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234