[ { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE", "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ], "http://www.nanopub.org/nschema#hasAssertion" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#pubinfo" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#Head" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#_1", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=4893" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#_2", "@type" : [ "http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000", "http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00696" ], "http://www.selventa.com/vocabulary/variantOf" : [ { "@id" : "http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6842" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#_3", "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ], "http://purl.obolibrary.org/obo/BFO_0000066" : [ { "@id" : "http://purl.obolibrary.org/obo/CLO_0008105" }, { "@id" : "http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#_2" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ { "@id" : "http://www.selventa.com/vocabulary/increases" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#_1" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#assertion", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "p(HGNC:HGF) -> p(HGNC:MAP2K2,pmod(P,S,225))" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#assertion" }, { "@graph" : [ { "@id" : "http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel", "http://purl.org/dc/elements/1.1/description" : [ { "@value" : "Approximately 61,000 statements." } ], "http://purl.org/dc/elements/1.1/rights" : [ { "@value" : "Copyright (c) 2011-2012, Selventa. All rights reserved." } ], "http://purl.org/dc/elements/1.1/title" : [ { "@value" : "BEL Framework Large Corpus Document" } ], "http://purl.org/pav/authoredBy" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#_5" } ], "http://purl.org/pav/version" : [ { "@value" : "20131211" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#_4", "http://www.w3.org/ns/prov#value" : [ { "@value" : "In c-MET-overexpressing SCLC cell line NCI-H69, hepatocyte growth factor (HGF) dramatically induced c-MET phosphorylation at phosphoepitopes pY1230/1234/1235 (catalytic tyrosine kinase), pY1003 (juxtamembrane), and also of paxillin at pY31 (CRKL-binding site). We utilised a global proteomics phosphoantibody array approach to identify further c-MET/HGF signal transduction intermediates in SCLC. Strong HGF induction of specific phosphorylation sites in phosphoproteins involved in c-MET/HGF signal transduction was detected, namely adducin-alpha [S724], adducin-gamma [S662], CREB [S133], ERK1 [T185/Y187], ERK1/2 [T202/Y204], ERK2 [T185/Y187], MAPKK (MEK) 1/2 [S221/S225], MAPKK (MEK) 3/6 [S189/S207], RB [S612], RB1 [S780], JNK [T183/Y185], STAT3 [S727], focal adhesion kinase (FAK) [Y576/S722/S910], p38alpha-MAPK [T180/Y182], and AKT1[S473] and [T308]. Conversely, we also identified modest inhibition of phosphorylation by HGF in the following phosphoproteins (Figures 2A and B): PKCa [S657], PKCa/b [T368/641], and PKCd [T505]. Moreover, HGF also inhibited phosphorylation of PKR [T451], which is known to have antiproliferative and pro-apoptotic functions. Lastly, HGF also reduced the threonine and tyrosine phosphorylation of the cell cycle checkpoint regulator CDK1 [T14/Y15]." } ], "http://www.w3.org/ns/prov#wasQuotedFrom" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/17667909" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#_5", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "Selventa" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#assertion", "http://www.w3.org/ns/prov#hadPrimarySource" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/17667909" } ], "http://www.w3.org/ns/prov#wasDerivedFrom" : [ { "@id" : "http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel" }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#_4" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#provenance" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE", "http://purl.org/dc/terms/created" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2014-07-03T14:33:12.105+02:00" } ], "http://purl.org/pav/createdBy" : [ { "@id" : "http://orcid.org/0000-0001-6818-334X" }, { "@id" : "http://orcid.org/0000-0002-1267-0234" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RADaEY71lCouVtbFlWSeyMbKdONb0vxdFsmcAL7mIhmqE#pubinfo" } ]