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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RADYEUjvq3NN7RQUzf7pB7y_CDBgdsUhWl34T5RKv_z4c#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RADYEUjvq3NN7RQUzf7pB7y_CDBgdsUhWl34T5RKv_z4c#_5 http://www.w3.org/ns/prov#value The tumor suppressor protein, p53 is a transcription factor that not only activates expression of genes containing the p53 binding site but also can repress the expression of some genes lacking this binding site. Previous studies have shown that overexpression of wild-type p53 leads to apoptosis and cell cycle arrest. DNA damage, such as that caused by UV irradiation, results in p53 stabilization and nuclear localization that subsequently induces apoptosis. Recently, the level of calreticulin (CRT) has been correlated with the rate of apoptosis. Therefore, the aim of this study was to investigate the role of CRT in the regulation of apoptosis via modulating p53 function and expression. Here we show a significant decrease in both basal and DNA damage induced p53 functions in the CRT-deficient cells (crt-/-). This study is the first to demonstrate that CRT function is required for the stability and localization of the p53 protein. By using immuonocytochemical techniques, we showed that observed changes in p53 in the crt-/- cells are due to the nuclear accumulation of Mdm2 (murine double minute gene). These results, lead us to conclude that CRT regulates p53 function by affecting its rate of degradation and nuclear localization. http://www.tkuhn.ch/bel2nanopub/RADYEUjvq3NN7RQUzf7pB7y_CDBgdsUhWl34T5RKv_z4c#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14767071 http://www.tkuhn.ch/bel2nanopub/RADYEUjvq3NN7RQUzf7pB7y_CDBgdsUhWl34T5RKv_z4c#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RADYEUjvq3NN7RQUzf7pB7y_CDBgdsUhWl34T5RKv_z4c#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14767071 http://www.tkuhn.ch/bel2nanopub/RADYEUjvq3NN7RQUzf7pB7y_CDBgdsUhWl34T5RKv_z4c#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RADYEUjvq3NN7RQUzf7pB7y_CDBgdsUhWl34T5RKv_z4c#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RADYEUjvq3NN7RQUzf7pB7y_CDBgdsUhWl34T5RKv_z4c#_5 http://www.tkuhn.ch/bel2nanopub/RADYEUjvq3NN7RQUzf7pB7y_CDBgdsUhWl34T5RKv_z4c#pubinfo http://www.tkuhn.ch/bel2nanopub/RADYEUjvq3NN7RQUzf7pB7y_CDBgdsUhWl34T5RKv_z4c http://purl.org/dc/terms/created 2014-07-03T14:32:16.197+02:00 http://www.tkuhn.ch/bel2nanopub/RADYEUjvq3NN7RQUzf7pB7y_CDBgdsUhWl34T5RKv_z4c http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RADYEUjvq3NN7RQUzf7pB7y_CDBgdsUhWl34T5RKv_z4c http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234