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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RADQ4szBSKedurawflr8eTBBvn9YykvewBZTMr2Ac4kuU#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RADQ4szBSKedurawflr8eTBBvn9YykvewBZTMr2Ac4kuU#_5 http://www.w3.org/ns/prov#value Here, we report that EGF-stimulation-induced Cbp tyrosine phosphorylation followed by Cbp-Csk association, in a SFK-dependent manner. Expression of wild-type (wt) Cbp remarkably suppressed EGF-induced activation of Src, ERK1/2, and Akt-1 enzymes, and NIH3T3 cell transformation, as well as colony formation of a breast cancer cell line (MDA-MB-468) in soft agar. In contrast, expression of CbpY317F or knockdown endogenous Cbp in NIH3T3 cells by RNA interference significantly enhanced EGF-induced activation of these enzymes and cell transformation. In addition, overexpression of multiple receptor tyrosine kinases (RTKs)-induced Cbp tyrosine phosphorylation. These results demonstrate that Cbp functions as a negative regulator of cell transformation and tumor cell growth through downregulation of Src activation, suggesting that Cbp might be broadly involved in RTKs-activated signaling pathways and tumorigenesis. http://www.tkuhn.ch/bel2nanopub/RADQ4szBSKedurawflr8eTBBvn9YykvewBZTMr2Ac4kuU#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16636672 http://www.tkuhn.ch/bel2nanopub/RADQ4szBSKedurawflr8eTBBvn9YykvewBZTMr2Ac4kuU#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RADQ4szBSKedurawflr8eTBBvn9YykvewBZTMr2Ac4kuU#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16636672 http://www.tkuhn.ch/bel2nanopub/RADQ4szBSKedurawflr8eTBBvn9YykvewBZTMr2Ac4kuU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RADQ4szBSKedurawflr8eTBBvn9YykvewBZTMr2Ac4kuU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RADQ4szBSKedurawflr8eTBBvn9YykvewBZTMr2Ac4kuU#_5 http://www.tkuhn.ch/bel2nanopub/RADQ4szBSKedurawflr8eTBBvn9YykvewBZTMr2Ac4kuU#pubinfo http://www.tkuhn.ch/bel2nanopub/RADQ4szBSKedurawflr8eTBBvn9YykvewBZTMr2Ac4kuU http://purl.org/dc/terms/created 2014-07-03T14:30:42.881+02:00 http://www.tkuhn.ch/bel2nanopub/RADQ4szBSKedurawflr8eTBBvn9YykvewBZTMr2Ac4kuU http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RADQ4szBSKedurawflr8eTBBvn9YykvewBZTMr2Ac4kuU http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234