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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RADNZyNTblp2mVg6hvEpORMHRrn4v8yFOZppjryu8qKeg#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RADNZyNTblp2mVg6hvEpORMHRrn4v8yFOZppjryu8qKeg#_3 http://www.w3.org/ns/prov#value The phytochemical resveratrol, found in grapes, berries and peanuts, has been found to possess cancer chemopreventive effects by inhibiting diverse cellular events associated with tumour initiation, promotion and progression. Resveratrol is also a phyto-oestrogen, binds to and activates oestrogen receptors that regulate the transcription of oestrogen-responsive target genes such as the breast cancer susceptibility genes BRCA1 and BRCA2. We investigated the effects of resveratrol on BRCA1 and BRCA2 expression in human breast cancer cell lines (MCF7, HBL 100 and MDA-MB 231) using quantitative real-time RT-PCR, and by perfusion chromatography of the proteins. All cell lines were treated with 30 microM resveratrol. The expressions of BRCA1 and BRCA2 mRNAs were increased although no change in the expression of the proteins were found. These data indicate that resveratrol at 30 micro M can increase expression of genes involved in the aggressiveness of human breast tumour cell lines. http://www.tkuhn.ch/bel2nanopub/RADNZyNTblp2mVg6hvEpORMHRrn4v8yFOZppjryu8qKeg#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12838319 http://www.tkuhn.ch/bel2nanopub/RADNZyNTblp2mVg6hvEpORMHRrn4v8yFOZppjryu8qKeg#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RADNZyNTblp2mVg6hvEpORMHRrn4v8yFOZppjryu8qKeg#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12838319 http://www.tkuhn.ch/bel2nanopub/RADNZyNTblp2mVg6hvEpORMHRrn4v8yFOZppjryu8qKeg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RADNZyNTblp2mVg6hvEpORMHRrn4v8yFOZppjryu8qKeg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RADNZyNTblp2mVg6hvEpORMHRrn4v8yFOZppjryu8qKeg#_3 http://www.tkuhn.ch/bel2nanopub/RADNZyNTblp2mVg6hvEpORMHRrn4v8yFOZppjryu8qKeg#pubinfo http://www.tkuhn.ch/bel2nanopub/RADNZyNTblp2mVg6hvEpORMHRrn4v8yFOZppjryu8qKeg http://purl.org/dc/terms/created 2014-07-03T14:30:14.145+02:00 http://www.tkuhn.ch/bel2nanopub/RADNZyNTblp2mVg6hvEpORMHRrn4v8yFOZppjryu8qKeg http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RADNZyNTblp2mVg6hvEpORMHRrn4v8yFOZppjryu8qKeg http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234