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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RADLjccVB5zJz1Ppc73R1eZ4Dx782aKwzj7IGQR2R3xsQ#_3 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RADLjccVB5zJz1Ppc73R1eZ4Dx782aKwzj7IGQR2R3xsQ#_2 http://www.w3.org/ns/prov#value In this study, we demonstrated that high glucose significantly increased intracellular ROS levels in human aortic endothelial cells (HAECs). Additionally, high glucose reduced the antioxidant activity of thioredoxin. To investigate the mechanisms involved, we found that glucose enhanced the expression of thioredoxin interacting protein (Txnip), a Trx inhibitory protein, through p38 mitogen-activated protein kinase (MAPK). We also showed that glucose regulated Txnip at transcription level and p38 MAPK and forkhead box O1 transcriptional factor (FOXO1) were involved in the process. http://www.tkuhn.ch/bel2nanopub/RADLjccVB5zJz1Ppc73R1eZ4Dx782aKwzj7IGQR2R3xsQ#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/19254690 http://www.tkuhn.ch/bel2nanopub/RADLjccVB5zJz1Ppc73R1eZ4Dx782aKwzj7IGQR2R3xsQ#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RADLjccVB5zJz1Ppc73R1eZ4Dx782aKwzj7IGQR2R3xsQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/19254690 http://www.tkuhn.ch/bel2nanopub/RADLjccVB5zJz1Ppc73R1eZ4Dx782aKwzj7IGQR2R3xsQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RADLjccVB5zJz1Ppc73R1eZ4Dx782aKwzj7IGQR2R3xsQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RADLjccVB5zJz1Ppc73R1eZ4Dx782aKwzj7IGQR2R3xsQ#_2 http://www.tkuhn.ch/bel2nanopub/RADLjccVB5zJz1Ppc73R1eZ4Dx782aKwzj7IGQR2R3xsQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RADLjccVB5zJz1Ppc73R1eZ4Dx782aKwzj7IGQR2R3xsQ http://purl.org/dc/terms/created 2014-07-03T14:33:33.456+02:00 http://www.tkuhn.ch/bel2nanopub/RADLjccVB5zJz1Ppc73R1eZ4Dx782aKwzj7IGQR2R3xsQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RADLjccVB5zJz1Ppc73R1eZ4Dx782aKwzj7IGQR2R3xsQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234