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[Based on odds ratio: (1) the SP-B intron 4 del variant in white subjects is more of an RDS risk factor for males and for subjects of 28 weeks <gestational age (GA)<33 weeks; (2) the SP-B intron 4 ins variant in black subjects is more of an RDS risk factor in females; (3) in white subjects, SP-A1 (6A(2)/6A(2)) or SP-A2 (1A(0)/1A(0) or 1A(0)/*) genotypes in subjects of certain GA and with a specific SP-B genotype (9306 (A/G) or del/*) are associated with an enhanced risk for RDS; (4) in black subjects, SP-A1 (6A3/6A(3) or 6A(3)/*) genotypes in subjects of 31 weeks < or = GA < or = 35 weeks and with the SP-B (1580 (T/T)) genotype are associated with a reduced risk for RDS.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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