@prefix this: <http://www.tkuhn.ch/bel2nanopub/RADGVS-pHki1MIEI6YVajX98QeKoTNNqJDxQ56dCG1wjU> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RADGVS-pHki1MIEI6YVajX98QeKoTNNqJDxQ56dCG1wjU#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix pfh: <http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-protein-families/> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix RNA: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasAgent: sub:_2;
    a go:0016301 .
  
  sub:_2 geneProductOf: pfh:AKT%20Family;
    a Protein: .
  
  sub:_3 geneProductOf: hgnc:12680;
    a RNA: .
  
  sub:_4 occursIn: species:9606;
    rdf:object sub:_3;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "kin(p(PFH:\"AKT Family\")) -> r(HGNC:VEGFA)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_6;
    pav:version "1.4" .
  
  sub:_5 prov:value "Overexpression of Akt led to upregulation of VEGF, increased production of superoxide ROS, and the switch to a more pronounced glycolytic metabolism ...  and ...  Second, Akt can induce expression of the ROS-generating enzyme NOX4....  From Full text...  We further demonstrated that Akt induced genes associated with resistance to ROS, including Sirt1 and rictor, and activation of the AP-1 subunit JunD....  ....And...  Treatment of this spontaneous melanoma with the Akt inhibitor resulted in significant decreases in 3 genes that may account for this resistance. Sirt1 is a deacetylase that attenuates p53 in the presence of oxidative stress; rictor is a rapamycin-insensitive member of the mammalian target of rapamycin complex; and VEGF is likely the major angiogenic factor in melanoma. Inhibition of Akt led to significant and reproducible decreases in the mRNA levels of all 3 genes.  .... Note: if they didnt not use an inhibitor to verify AKT action, I coded to expression of AKT.  If they used an inhibitor to verify action,  coded to kaof (AKT)";
    prov:wasQuotedFrom pubmed:17318262 .
  
  sub:_6 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:17318262;
    prov:wasDerivedFrom beldoc:, sub:_5 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:30:49.391+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}