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[Therefore, we investigated whether increased expression of PGC-1? would exert beneficial effects in the Tg19959 transgenic mouse model of AD; Tg19959 mice express the human amyloid precursor gene (APP) with 2 familial AD mutations and develop increased ?-amyloid levels, plaque deposition, and memory deficits by 2-3 mo of age.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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