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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAD7pfDauu8F0ttl-tuNdwo-CVZxUd2ItR4EWH9uzRGlI#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAD7pfDauu8F0ttl-tuNdwo-CVZxUd2ItR4EWH9uzRGlI#_5 http://www.w3.org/ns/prov#value We further demonstrate that these events are Src family tyrosine kinase-dependent and specifically identify the role of hematopoietic cell kinase (Hck) as a new Gab family adapter protein kinase. Conversely, inhibition of Src family tyrosine kinases by the pyrazolopyrimidine PP2, as in kinase-inactive Hck mutants, significantly reduces IL-6-triggered activation of extracellular signal-regulated kinase and AKT-1, leading to significant reduction of multiple myeloma cell proliferation and survival. Taken together, these results delineate a key role for Hck-mediated phosphorylation of Gab1 and Gab2 docking proteins in IL-6-induced proliferation and survival of multiple myeloma cells and identify tyrosine kinases and downstream adapter proteins as potential new therapeutic targets in multiple myeloma. http://www.tkuhn.ch/bel2nanopub/RAD7pfDauu8F0ttl-tuNdwo-CVZxUd2ItR4EWH9uzRGlI#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15010462 http://www.tkuhn.ch/bel2nanopub/RAD7pfDauu8F0ttl-tuNdwo-CVZxUd2ItR4EWH9uzRGlI#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAD7pfDauu8F0ttl-tuNdwo-CVZxUd2ItR4EWH9uzRGlI#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15010462 http://www.tkuhn.ch/bel2nanopub/RAD7pfDauu8F0ttl-tuNdwo-CVZxUd2ItR4EWH9uzRGlI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAD7pfDauu8F0ttl-tuNdwo-CVZxUd2ItR4EWH9uzRGlI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAD7pfDauu8F0ttl-tuNdwo-CVZxUd2ItR4EWH9uzRGlI#_5 http://www.tkuhn.ch/bel2nanopub/RAD7pfDauu8F0ttl-tuNdwo-CVZxUd2ItR4EWH9uzRGlI#pubinfo http://www.tkuhn.ch/bel2nanopub/RAD7pfDauu8F0ttl-tuNdwo-CVZxUd2ItR4EWH9uzRGlI http://purl.org/dc/terms/created 2014-07-03T14:32:17.698+02:00 http://www.tkuhn.ch/bel2nanopub/RAD7pfDauu8F0ttl-tuNdwo-CVZxUd2ItR4EWH9uzRGlI http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAD7pfDauu8F0ttl-tuNdwo-CVZxUd2ItR4EWH9uzRGlI http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234