@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAD55w8Nkn8_SueN0mMonYYG1S6ndgqjqm93n-2kaeBRM> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAD55w8Nkn8_SueN0mMonYYG1S6ndgqjqm93n-2kaeBRM#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix proteinModification: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
  this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
  sub:_1 belv:hasSubstitution "K,422,Q" ;
    belv:variantOf hgnc:9236 ;
    a proteinModification: .
  sub:_2 hasAgent: sub:_3 ;
    a go:0042789 .
  sub:_3 geneProductOf: hgnc:9236 ;
    a Protein: .
  sub:_4 occursIn: obo:CLO_0003666 , species:9606 ;
    rdf:object sub:_2 ;
    rdf:predicate belv:directlyDecreases ;
    rdf:subject sub:_1 ;
    a rdf:Statement .
  sub:assertion rdfs:label "p(HGNC:PPARG,sub(K,422,Q)) =| tscript(p(HGNC:PPARG))" .
}
sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_6 ;
    pav:version "20131211" .
  sub:_5 prov:value "All four resistant lines contained a monoallelic point mutation in the PPAR{gamma} gene at codon 422 resulting in a  change from lysine (Lys) to glutamine (Gln) (K422Q); this mutation was not found in the four sensitive cell lines (Table I). The correlation between the K422Q allele and lack of sensitivity to PPAR{gamma} ligands provided suggestive, but not definitive, evidence that this mutation caused the HCT 15, MIP 101, Clone A, and COLO 205 cell lines to be resistant to the growth inhibitory effects of PPAR{gamma} ligands." ;
    prov:wasQuotedFrom pubmed:12591919 .
  sub:_6 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:12591919 ;
    prov:wasDerivedFrom beldoc: , sub:_5 .
}
sub:pubinfo {
  this: dct:created "2014-07-03T14:31:59.011+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}