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a(CHEBI:bilirubin) -| a(CHEBI:"reactive oxygen species")
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Approximately 61,000 statements.
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Copyright (c) 2011-2012, Selventa. All rights reserved.
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BEL Framework Large Corpus Document
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HO-1 is a cytoprotective enzyme (6) that degrades the potent prooxidant heme to generate CO and bilirubin. CO is a vasodilatory gas that has anti-proliferative effects on vascular smooth muscle cells (VSMCs) (7) and has anti-inflammatory properties (8). Bilirubin is a scavenger for reactive oxygen species (ROS) (9). In addition, ferrous ion, another product of HO-1, upregulates ferritin, which also has scavenger activity.
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Selventa
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2014-07-03T14:30:53.335+02:00
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