. . . . . . . . . "a(CHEBI:bilirubin) -| a(CHEBI:\"reactive oxygen species\")" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "HO-1 is a cytoprotective enzyme (6) that degrades the potent prooxidant heme to generate CO and bilirubin. CO is a vasodilatory gas that has anti-proliferative effects on vascular smooth muscle cells (VSMCs) (7) and has anti-inflammatory properties (8). Bilirubin is a scavenger for reactive oxygen species (ROS) (9). In addition, ferrous ion, another product of HO-1, upregulates ferritin, which also has scavenger activity." . . "Selventa" . . . . "2014-07-03T14:30:53.335+02:00"^^ . . .