http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#Head http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#assertion http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#provenance http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#pubinfo http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#assertion http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#_1 http://www.selventa.com/vocabulary/variantOf http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=16971 http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000 http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00696 http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#_1 http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://resource.belframework.org/belframework/20131211/namespace/selventa-legacy-chemicals/serum%20insulin http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#assertion http://www.w3.org/2000/01/rdf-schema#label a(SCHEM:"serum insulin") -> p(HGNC:FRS2,pmod(P,T)) http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#_3 http://www.w3.org/ns/prov#value Here we demonstrate that, in addition to tyrosine phosphorylation, FRS2alpha is phosphorylated by MAP kinase on multiple threonine residues in response to FGF stimulation or by insulin, EGF, and PDGF, extracellular stimuli that do not induce tyrosine phosphorylation of FRS2alpha. Prevention of FRS2alpha threonine phosphorylation results in constitutive tyrosine phosphorylation of FRS2alpha in unstimulated cells and enhanced tyrosine phosphorylation of FRS2alpha, MAPK stimulation, cell migration, and proliferation in FGF-stimulated cells. http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12419216 http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12419216 http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#_3 http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM#pubinfo http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM http://purl.org/dc/terms/created 2014-07-03T14:31:56.291+02:00 http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAD1xDum4J76opun3ARpaLQPXblninK3uoAlj6yOCYlwM http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234