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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RACxot7Pxici2kGoP8UUES1AQeD2GJidJZfgYs8ufBSMQ#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RACxot7Pxici2kGoP8UUES1AQeD2GJidJZfgYs8ufBSMQ#_3 http://www.w3.org/ns/prov#value The distinct effect of diabetes induction on the pattern of rat plasma proteins includes the down-regulation of albumin, apolipoprotein E (Apo E), alpha(1)-inhibitor-3, fetuin beta, Gc-globulin, hemopexin, vitronectin, and transthyretin (TTR) monomer, and the up-regulation of Apo A-I, Apo A-IV, ceruloplasmin, alpha(1)-antitrypsin, serine protease inhibitor III, and transferrin. Those protein levels were interestingly restored to those of healthy rats by EPS treatment, although the order of magnitude of the changes differed widely. Two proteins of interest showed distinct differential expression with opposite trends: TTR tetramer was significantly down-regulated and immunoglobulin (Ig) kappa light chain was significantly up-regulated upon diabetes induction, both of which were also normalized to those of healthy groups after EPS treatment. http://www.tkuhn.ch/bel2nanopub/RACxot7Pxici2kGoP8UUES1AQeD2GJidJZfgYs8ufBSMQ#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16947119 http://www.tkuhn.ch/bel2nanopub/RACxot7Pxici2kGoP8UUES1AQeD2GJidJZfgYs8ufBSMQ#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RACxot7Pxici2kGoP8UUES1AQeD2GJidJZfgYs8ufBSMQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16947119 http://www.tkuhn.ch/bel2nanopub/RACxot7Pxici2kGoP8UUES1AQeD2GJidJZfgYs8ufBSMQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RACxot7Pxici2kGoP8UUES1AQeD2GJidJZfgYs8ufBSMQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RACxot7Pxici2kGoP8UUES1AQeD2GJidJZfgYs8ufBSMQ#_3 http://www.tkuhn.ch/bel2nanopub/RACxot7Pxici2kGoP8UUES1AQeD2GJidJZfgYs8ufBSMQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RACxot7Pxici2kGoP8UUES1AQeD2GJidJZfgYs8ufBSMQ http://purl.org/dc/terms/created 2014-07-03T14:30:45.868+02:00 http://www.tkuhn.ch/bel2nanopub/RACxot7Pxici2kGoP8UUES1AQeD2GJidJZfgYs8ufBSMQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RACxot7Pxici2kGoP8UUES1AQeD2GJidJZfgYs8ufBSMQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234