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composite(p(EGID:3082),a(CHEBI:cisplatin)) -| r(HGNC:RRM2)
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Approximately 61,000 statements.
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Copyright (c) 2011-2012, Selventa. All rights reserved.
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BEL Framework Large Corpus Document
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1.4
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Genes modulated only in response to the combined treatment with HGF and CDDP, but not by the single treatment, are particularly interesting as they could be better relatedtoHGF-mediated sensitization toCDDP. In fact, this is a distinctive response of ovarian cancer cells as shown in several ovarian cancer cell lines (8, 11). In this group, those above all down-modulated were PANK3, RAMP, RRM2, and TDG. Most of them have been already associated to cell proliferation and apoptosis and even to cancer cell resistance
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Selventa
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2014-07-03T14:30:43.345+02:00
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